Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Synthesis of gold nanoparticles exhibition wide range bioactivities and was conventionally used for the remedy numerous disorders. Our study aims to measure gastroprotective effect synthesized on absolute ethanol-induced stomach ulceration in rats. The rats were noticeably administered with two doses (175 ppm 350 ppm) alcohol showed a significant improvement adverse ethanol-produced damage as confirmed by decreasing ulcer index raising % prevention. Increased mucus pH content reduced ulcerated portion, condensed or nonappearance edema, white blood cells permeation subcutaneous layer. In gastric tissue homogenate, presented substantial increase superoxide dismutase (SOD), catalase (CAT) actions, lessening malondialdehyde (MDA) amount. Besides, nanoparticle increases intensity periodic acid Schiff stained (PAS) epithelium stomach. Gold gastro-protective effects which might be qualified its antioxidant, secretion, endogenous enzymes (SOD CAT), reduce MDA quantity.